Ndnf - neuron-derived neurotrophic factor

Predicted to enable heparin binding activity. Predicted to be involved in several processes, including gonadotrophin-releasing hormone neuronal migration to the hypothalamus; negative regulation of apoptotic process; and response to ischemia. Predicted to act upstream of or within extracellular matrix organization; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; and positive regulation of cell-substrate adhesion. Predicted to be located in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]