Hm13 - histocompatibility minor 13

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; protein homodimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol and signal peptide processing. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cell surface; endoplasmic reticulum membrane; and rough endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Orthologous to human HM13 (histocompatibility minor 13). [provided by Alliance of Genome Resources, Apr 2022]