Predicted to enable Notch binding activity. Predicted to be involved in several processes, including cellular response to growth factor stimulus; circulatory system development; and regulation of Notch signaling pathway. Predicted to act upstream of or within angiogenesis; negative regulation of blood vessel endothelial cell migration; and regulation of neurogenesis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]