Zeb2 - zinc finger E-box binding homeobox 2

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Predicted to be located in chromatin; cytosol; and nuclear lumen. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]