Hjv - hemojuvelin BMP co-receptor

Predicted to enable BMP binding activity; coreceptor activity; and transferrin receptor binding activity. Predicted to contribute to BMP receptor activity. Predicted to be involved in several processes, including cellular iron ion homeostasis; protein autoprocessing; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within iron ion homeostasis; negative regulation of BMP signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Apr 2022]