Arhgef2 - Rho/Rac guanine nucleotide exchange factor 2

Predicted to enable guanyl-nucleotide exchange factor activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including generation of neurons; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of podosome assembly. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]