RT1-CE5 - RT1 class I, locus CE5

Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and beta-2-microglobulin binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and regulation of lymphocyte mediated immunity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Apr 2022]