Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]