Bin1 - bridging integrator 1

Enables aspartic-type endopeptidase inhibitor activity and tau protein binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; negative regulation of cation transmembrane transport; and regulation of heart contraction. Acts upstream of or within muscle cell differentiation. Located in several cellular components, including T-tubule; dendrite; and nuclear envelope. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart; and musculature. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Apr 2022]