Zbtb18 - zinc finger and BTB domain containing 18

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and skeletal muscle tissue development. Acts upstream of or within several processes, including in utero embryonic development; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeleton. Used to study autosomal dominant non-syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]