Fan1 - FANCD2 and FANCI associated nuclease 1

Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-dependent protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair, DNA incision. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Apr 2022]