Foxe3 - forkhead box E3

Enables sequence-specific DNA binding activity. Involved in camera-type eye development; negative regulation of lens fiber cell differentiation; and positive regulation of lens epithelial cell proliferation. Acts upstream of or within camera-type eye development; cell development; and positive regulation of epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and heart. Used to study congenital aphakia. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3). [provided by Alliance of Genome Resources, Apr 2022]