Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; histone binding activity; and histone methyltransferase activity (H4-K20 specific). Predicted to be involved in DNA repair; histone H4-K20 trimethylation; and positive regulation of DNA metabolic process. Predicted to act upstream of or within histone methylation. Predicted to be located in condensed chromosome, centromeric region; nucleoplasm; and pericentric heterochromatin. Predicted to be active in nucleus. Biomarker of liver benign neoplasm. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]