Bicd2 - BICD cargo adaptor 2

This gene encodes a dynein-dynactin adaptor protein. In mouse, the protein primarily localizes to the Golgi complex as well as to microtubule plus ends through dynactin. Overexpression studies suggest that the N-terminus mediates the dynein-dynactin interaction, while the C-terminus is responsible for Golgi targeting. Knockout of this gene in mouse results in a defect in cerebellar granule cell migration. In human, mutations in this gene are associated with spinal muscular dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]