Nsd1 - nuclear receptor binding SET domain protein 1

Predicted to enable several functions, including histone-lysine N-methyltransferase activity; nuclear receptor binding activity; and zinc ion binding activity. Predicted to be involved in histone methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within gastrulation with mouth forming second; regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; and regulation of protein modification process. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]