Irx2 - iroquois homeobox 2

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to act upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Orthologous to human IRX2 (iroquois homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]