Bap1 - Brca1 associated protein 1

Predicted to enable chromatin binding activity and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including negative regulation of transcription, DNA-templated; positive regulation of protein targeting to mitochondrion; and protein deubiquitination. Predicted to act upstream of or within several processes, including macrophage homeostasis; regulation of cytokine production involved in inflammatory response; and regulation of inflammatory response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal cell carcinoma and extrahepatic bile duct adenocarcinoma. Orthologous to human BAP1 (BRCA1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]