Nkx3-1 - NK3 homeobox 1

Predicted to enable several functions, including MADS box domain binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and estrogen receptor binding activity. Predicted to be involved in several processes, including morphogenesis of a branching epithelium; positive regulation of cell communication; and regulation of gene expression. Predicted to act upstream of or within animal organ development; chordate embryonic development; and dorsal aorta development. Predicted to be located in cytosol; nucleoplasm; and site of DNA damage. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]