Vcl - vinculin

Enables small GTPase binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; platelet aggregation; and protein localization to cell surface. Predicted to act upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in Z disc; intercalated disc; and sarcolemma. Colocalizes with actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]