Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; circadian rhythm; and response to lithium ion. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Apr 2022]