Enables methylenetetrahydrofolate dehydrogenase (NADP+) activity. Involved in 10-formyltetrahydrofolate metabolic process and tetrahydrofolate interconversion. Located in mitochondrial inner membrane and mitochondrial matrix. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like). [provided by Alliance of Genome Resources, Apr 2022]