Atf6 - activating transcription factor 6

Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to act upstream of or within positive regulation of autophagy and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Biomarker of borna disease. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]