F5 - coagulation factor V

Predicted to enable oxidoreductase activity. Involved in blood coagulation and response to vitamin K. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Used to study membranoproliferative glomerulonephritis. Biomarker of hepatitis and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V). [provided by Alliance of Genome Resources, Apr 2022]