Sirt4 - sirtuin 4

Predicted to enable NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Biomarker of non-alcoholic fatty liver disease. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]