Predicted to enable ubiquitin protein ligase activity. Involved in protein catabolic process, modulating synaptic transmission. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Apr 2022]