Arhgef18 - Rho/Rac guanine nucleotide exchange factor 18

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly and protein localization to cell-cell junction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]