Smurf2 - SMAD specific E3 ubiquitin protein ligase 2

Enables SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]