Map3k3 - mitogen activated protein kinase kinase kinase 3

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of cellular senescence; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within several processes, including blood vessel development; positive regulation of p38MAPK cascade; and protein autophosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]