Plekhm1 - pleckstrin homology and RUN domain containing M1

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including autophagosome-lysosome fusion; positive regulation of bone resorption; and positive regulation of ruffle assembly. Predicted to be located in autolysosome and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to human PLEKHM1 (pleckstrin homology and RUN domain containing M1). [provided by Alliance of Genome Resources, Apr 2022]