Irgm - immunity-related GTPase M

Predicted to enable several functions, including GTPase activity; protein domain specific binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of protein phosphorylation; and response to bacterium. Predicted to act upstream of or within cellular response to interferon-gamma and response to bacterium. Predicted to be located in several cellular components, including Golgi membrane; autolysosome; and cytoplasmic vesicle. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2022]