Glis2 - GLIS family zinc finger 2

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Predicted to act upstream of or within hematopoietic stem cell homeostasis; kidney development; and positive regulation of protein localization to nucleus. Predicted to be located in cytoplasm; non-motile cilium; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]