Zap70 - zeta chain of T cell receptor associated protein kinase 70

Predicted to enable several functions, including ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and immunological synapse. Predicted to be part of T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with membrane raft. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Apr 2022]