Hsp90ab1 - heat shock protein 90 alpha family class B member 1

Enables nucleotide binding activity; sulfonylurea receptor binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; positive regulation of protein import into nucleus; and regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and ooplasm. Biomarker of muscular atrophy; pancreatitis; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Apr 2022]