Krt1 - keratin 1

Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including complement activation, lectin pathway; protein heterotetramerization; and retina homeostasis. Predicted to act upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Predicted to be located in cornified envelope and keratin filament. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis; epidermolytic palmoplantar keratoderma; and nonepidermolytic palmoplantar keratoderma. Orthologous to human KRT1 (keratin 1). [provided by Alliance of Genome Resources, Apr 2022]