Irak4 - interleukin-1 receptor-associated kinase 4

Predicted to enable interleukin-1 receptor binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]