Srebf2 - sterol regulatory element binding transcription factor 2

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription, DNA-templated; response to lead ion; and spermatogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm; dendrite; and nucleus. Biomarker of kidney disease (multiple); lipid storage disease; obesity; and visual epilepsy. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]