Dicer1 - dicer 1 ribonuclease III

Predicted to enable RNA binding activity; endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; and protein domain specific binding activity. Predicted to contribute to pre-miRNA binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of cell population proliferation; and positive regulation of collagen biosynthetic process. Located in several cellular components, including dendrite; endoplasmic reticulum-Golgi intermediate compartment; and growth cone. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]