Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]