Enables NADP binding activity; carbohydrate binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in NADP metabolic process; carbohydrate metabolic process; and response to alcohol. Located in mitochondrion. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]