Lag3 - lymphocyte activating 3

Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]