Edem1 - ER degradation enhancing alpha-mannosidase like protein 1

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Predicted to be involved in positive regulation of retrograde protein transport, ER to cytosol; protein alpha-1,2-demannosylation; and protein targeting to ER. Predicted to act upstream of or within ubiquitin-dependent ERAD pathway. Predicted to be located in aggresome and endoplasmic reticulum quality control compartment. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2022]