Crbn - cereblon

Enables transmembrane transporter binding activity. Involved in negative regulation of ion transmembrane transport; negative regulation of protein-containing complex assembly; and positive regulation of protein-containing complex assembly. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Apr 2022]