Slc19a1 - solute carrier family 19 member 1

Enables folate:anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in female pregnancy; folic acid transport; and methotrexate transport. Located in apical plasma membrane; basolateral plasma membrane; and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Apr 2022]