Scn8a - sodium voltage-gated channel alpha subunit 8

Enables sodium ion binding activity and voltage-gated sodium channel activity. Involved in nervous system development; neuronal action potential; and sodium ion transport. Located in axon initial segment; node of Ranvier; and plasma membrane. Is integral component of membrane. Part of voltage-gated sodium channel complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]