Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in cellular response to cytokine stimulus; monocyte differentiation; and signal transduction. Predicted to act upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Located in neuronal cell body. Biomarker of Parkinsonism. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2022]