Scn1b - sodium voltage-gated channel beta subunit 1

Enables sodium channel regulator activity. Involved in regulation of voltage-gated sodium channel activity and response to pyrethroid. Is integral component of plasma membrane. Part of voltage-gated sodium channel complex. Colocalizes with node of Ranvier. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]