Pon2 - paraoxonase 2

Predicted to enable arylesterase activity and identical protein binding activity. Involved in response to oxidative stress. Located in lysosome; mitochondrion; and nucleus. Biomarker of non-alcoholic fatty liver disease and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Apr 2022]