Adam10 - ADAM metallopeptidase domain 10

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including dendritic spine; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Apr 2022]