Hsd3b2 - hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]