Usp8 - ubiquitin specific peptidase 8

Predicted to enable thiol-dependent deubiquitinase. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in cytosol and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]